曹志贱/Zhijian Cao

教授、博士、国家优秀青年基金获得者

教育经历/Education

1999/09-2004/06，武汉大学，博士

1994/09-1998/07，武汉大学，学士

工作经历/ Professional Experience

2024/02-至今：韩19+vip仙女屋瑟妃，教授

2015/02-2024/01：武汉大学生命科学学院/病毒学国家重点实验室，教授

2014/02-2015/01：美国梅哈里医学院，访问学者

2006/12-2014/01：武汉大学生命科学学院/病毒学国家重点实验室，副教授

2004/07-2006/11：武汉大学生命科学学院/病毒学国家重点实验室，讲师

1998/07-1999/08：湖南省畜牧兽医研究所，研究实习员

研究方向/Research Fields

1)动物毒素活性多肽的药用基础

2)抗病毒多肽药物的筛选与鉴定

基金资助/Fund Support

1) 国家自然科学基金委员会面上项目、No.32370547、2024/01-2027/12、主持。

2) 国家自然科学基金委员会国际（地区）合作项目、No.32161160303、2022/01-2024/12、主持。

3) 国家自然科学基金委员会面上项目、No.32070525、2021/01-2024/12、主持。

4) 国家自然科学基金委员会面上项目、No.31872239、2019/01-2022/12、主持。

5) 国家自然科学基金委员会面上项目、No.31572289、2016/01-2019/12、主持。

6) 国家自然科学基金委员会优秀青年基金项目、No.31422049、2015/01-2017/12、主持。

7) 国家“十一五”重大新药专项项目、No.2009ZX09103-612、2009/01-2012/12、主持。

8) 国家重点研发计划项目、No.2023YFC2307803、2024/01-2026/12、参与。

9) 深圳市科创委基础研究面上项目、No.JCYJ20230807090212024、2023/11-2026/11、主持。

10) 湖北省杰出青年基金项目、No.2015CFA042、2015/01-2017/12、主持。

研究概述/Research Description

蝎作为“五毒”之首，在我国和一些中东国家，几千年以来人们一直使用蝎作为传统药物使用。蝎的药用价值主要来源于其尾部毒腺分泌的毒液，其药用成分是具有多种生物活性的毒素多肽。1999年以来，团队一直从事以蝎为代表的动物毒素多肽药用基础特别是抗病毒研究，在Nature Communications（IF=16.6）、J Allergy Clin Immunol（IF=14.2）、Biomaterials（IF=14）、Theranostics（IF=12.4）、PLoS Biology（IF=9.8）等杂志以第一或通讯作者发表SCI论文70篇。相关研究结果已申请国家发明专利24项，其中授权12项，且有2项获国家重大新药创制专项项目资助。

代表性学术论文和专著/ Selected Publications and Books

1) Cao Z^#, Yu Y^#, Wu Y^#, Hao P^#, Di Z^#, He Y^#, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W. The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods.Nat Commun. 2013,4:2602.(IF=16.6)

2) Li X, Yang H, Han Y, Yin S, Shen B, Wu Y, Li W,Cao Z*. Tick peptides evoke itch by activating MrgprC11/X1 to sensitize downstream TRPV1 in pruriceptors.J Allergy Clin Immunol.2021 Jun;147(6):2236-2248. (IF=14.2)

3) Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W,Cao Z*.Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.Biomaterials. 2013,34(13):3511-3522.(IF=14)

4) Yu XF, Sun Z, Li M, Xiang Y, Wang QQ*, Tang F, Wu Y,Cao Z*, Li W*.Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation.Biomaterials. 2010,31(33): 8724-8731.(IF=14)

5) Cheng Y, Sun F, Wang L, Gao M, Xie Y, Sun Y, Liu H, Yuan Y, Yi W, Huang Z, Yan H, Peng K, Wu Y,Cao Z*. Virus-induced p38 MAPK activation facilitates viral infection.Theranostics.2020 Oct 30;10(26):12223-12240.(IF=12.4)

6) Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y*,Cao Z*. Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1.Theranostics. 2018, 8(1):199-211.(IF=12.4)

7) Gan B, Yu L, Yang H, Jiao H, Pang B, Chen Y, Wang C, Lv R, Hu H,Cao Z*, Ren R*. Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.PLoS Biol.2023 Jun 22;21(6):e3001975. (IF=9.8)

8) Fan S, Sun Z, Jiang D, Dai C, Ma Y, Zhao Z, Liu H, Wu Y,Cao Z*, Li W*. BmKCT toxin inhibits glioma proliferation and tumor metastasis.Cancer Lett. 2010,291(2):158-166.(IF=9.7)

9) Xia Z, He D, Wu Y, Kwok HF*, Cao Z*. Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers.Pharmacological Research, 2023, 197:106978.(IF=9.3)

10) Sun F, Mu C, Kwok HF, Xu J, Wu Y, Liu W, Sabatier JM, Annweiler C, Li X*,Cao Z*, Xie Y*.Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19.Int J Biol Sci.2021,17(9):2348-2355.(IF=9.2)

11) Zeng Z, Han S, Hong W, Lang Y, Li F, Liu Y, Li Z, Wu Y, Li W, Zhang X*,Cao Z*. A tat-conjugated peptide nucleic acid Tat-PNA-DR inhibits hepatitis B virus replication in vitro and in vivo by targeting LTR direct repeats of HBV RNA.Mol Ther Nucleic Acids. 2016,5:e295.(IF=8.8)

12) Xia Z, Ren Y, Li S, Xu J, Wu Y,Cao Z*. ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activity.Antiviral Res.2021,195:105193.(IF=7.6)

13) Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, Miao L*,Cao Z*. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Antiviral Res.2020,182:104922.(IF=7.6)

14) Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W,Cao Z*. Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1.Antiviral Res. 2014,102:1-10.(IF=7.6)

15) de Seabra Rodrigues Dias IR,Cao Z*, Kwok HF*. Adamalysins in COVID-19 - Potential mechanisms behind exacerbating the disease.Biomed Pharmacother.2022, 150:112970. (IF=7.5)

16) Chen B, Li F, Zhu XK, Xie W, Hu X, Zan MH, Li X, Li QY, Guo SS, Zhao XZ, Jiang YA*,Cao Z*, Liu W*.Highly biocompatible and recyclable biomimetic nanoparticles for antibiotic-resistant bacteria infection.Biomater Sci.2021,9(3):826-834.(IF=6.6)

17) Wang L, Xia Z, Tang W, Sun Y, Wu Y, Kwok HF*, Sun F*, Cao Z*. p38 activation and viral infection.Expert Rev Mol Med.2022, 24:e4.(IF=6.2)

18) Wang L, Sun F, Hu J, Zuo W, Zheng Y, Wu Y,Kwok HF*,Cao Z*. The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway.Arch Toxicol.2023 Jun;97(6):1783-1794. (IF=6.1)

19) Qin H, Zuo W, Ge L, Siu SWI, Wang L, Chen X, Ma C, Chen T, Zhou M,Cao Z*,Kwok HF*. Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue.Comput Struct Biotechnol J.2023 May 6;21:2960-2972. (IF=6.0)

20) Liu G, Yang F, Li F, Li Z, Lang Y, Shen B, Wu Y, Li W, Harrison PL, Strong PN, Xie Y, Miller K*,Cao Z*. Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant gram-positive bacteria.Front Microbiol. 2018 May 29;9:1159.(IF=5.2)

21) Lang Y, Li F, Liu Q, Xia Z, Ji Z, Hu J, Cheng Y, Gao M, Sun F, Shen B, Xie C, Yi W, Wu Y, Yao J*,Cao Z*. The Kv1.3 ion channel acts as a host factor restricting viral entry.FASEB J. 2021,35(2):e20995.(IF=4.8)

22) Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W*,Cao Z*.Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus.Antimicrob Agents Chemother. 2011,55(11):5220-5229.(IF=4.9)

23) Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y,Cao Z*, Li W*.Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates.Antimicrob Agents Chemother. 2009,83:3472-3477.(IF=4.9)

24) Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y,Cao Z*, Li W*.Mucroporin, the first cationic host defence peptide from the venom of Lychas mucronatus.Antimicrob Agents Chemother. 2008,52(11): 3967-3972.(IF=4.9)

25) Li F, Lang Y, Ji Z, Xia Z, Han Y, Cheng Y, Liu G, Sun F, Zhao Y, Gao M, Chen Z, Wu Y, Li W,Cao Z*.A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles.J Biol Chem. 2019 Jan 4;294(1):182-194.(IF=4.8)

26) Meng L, Xie Z, Zhang Q, Li Y, Yang F, Chen Z, Li W,Cao Z*, Wu Y*. Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin.J Biol Chem. 2016,291(13):7097-106.(IF=4.8)

27) Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W,Cao Z*. A p7 ion channel-derived peptide inhibits hepatitis C virus infection in vitro.J Biol Chem.2015,290(38):23254-23263. (IF=4.8)

28) Song Y, Gong K, Yan H, Hong W, Wang L, Wu Y, Li W*, Li W*,Cao Z*. Sj7170, a unique dual-functional peptide with a specificα-chymotrypsin inhibitory activity and a potent tumor activating effect from scorpion venom.J Biol Chem.2014,289(17):11667-11680.(IF=4.8)

29) Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W*,Cao Z*.Mucroporin-M1 inhibits Hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) Pathway and down-regulating HNF4αin vitroandin vivo.J Biol Chem. 2012,287(36):30181-30190.(IF=4.8)

30) Sun F, Xia Z, Han Y, Gao M, Wang L, Wu Y, Sabatier JM, Miao L,Cao Z*. Topology, antiviral functional residues and mechnism of IFITM1.Viruses. 2020;12:295.(IF=4.7)

31) Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y*,Cao Z*. K1K8: an Hp1404-derived antibacterial peptide.Appl Microbiol Biotechnol. 2016, 100(11):5069-5077.(IF=5.0)

32) Di Z, Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X*, Li W*,Cao Z*. Genome-wide analysis of homeobox genes from Mesobuthus martensii reveals Hox gene duplication in scorpions.Insect Biochem Mol Biol.2015,61:25-33.(IF=3.8)

33) Cheng Y, Sun F, Li S, Gao M, Wang L, Sarhan M, Abdel-Rahman MA, Li W, Kwok HF, Wu Y,Cao Z*. Inhibitory activity of a scorpion defensin BmKDfsin3 against hepatitis C virus.Antibiotics (Basel). 2020 Jan 17;9(1).(IF=4.8)

34) Zeng Z, Zhang Q, Hong W, Xie Y, Liu Y, Li W, Wu Y,Cao Z*. A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replicationin vitro.Toxins (Basel). 2016,8(5).(IF=4.2)

35) 《蝎生物学与毒素》，李文鑫、吴英亮、曹志贱、邸智勇，2016年11月，北京，科学出版社。

联系方式/Contact

E-mail: 20241002@hbut.edu.cn

人才招聘/Talent Recruitment

热诚欢迎有志于从事生物活性多肽的药物化学、生物信息学、药物学（抗病毒药物）、毒理学（神经毒理）等研究的博士和学生，以教师、博士后、博士研究生或者硕士研究生的身份加入研究团队，携手合作，共创未来。